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That freedom from constant food thinking was worth the price of admission on its own

Specifically, be concerned if weight loss stalls completely for more than 3 weeks despite caloric deficit, if appetite suppression is noticeably weaker than during initial weeks, if you do not notice any thermogenic effect, or if your weekly weight loss rate drops below half of what clinical trials show for your dose level

Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham L, Anis AH

Cardiovascular Safety Metformin has demonstrated cardiovascular safety and may provide cardiovascular benefit in certain patient populations with type 2 diabetes